Natasha Henstridge

Character: Lt. Melanie Ballard

Ice Cube

Character: James 'Desolation' Williams

Pam Grier

Character: Commander Helena Braddock

Jason Statham

Character: Sgt. Jericho Butler

Clea DuVall

Character: Bashira Kincaid

Joanna Cassidy

Character: Dr. Arlene Whitlock

Richard Cetrone

Character: Big Daddy Mars

Rosemary Forsyth

Character: Inquisitor

Liam Waite

Character: Michael Descanso

Duane Davis

Character: Uno

Lobo Sebastian

Character: Dos

Rodney A. Grant

Character: Tres

Wanda De Jesus

Character: Akooshay

Peter Jason

Character: Engineer McSimms

Doug McGrath

Character: Benchley

Rick Edelstein

Character: Zimmerman

Rex Linn

Character: Yared

Michael Krawic

Character: Man in the Rover

Robert Carradine

Character: Rodale

Eileen Weisinger

Character: Woman Warrior

Marjean Holden

Character: Young Woman

Matt Nolan

Character: Miner

Charlotte Cornwell

Character: Narrator (voice)

Danielle Burgio

Character: Local Lady Cop (uncredited)

Lena Milan

Character: Hand-Double (uncredited)

Damon Caro

Character: Shape-Male Intern (uncredited)

Christopher Allen Nelson

Character: Demon Miner (uncredited)