Anika Noni Rose

Character: Tiana (voice)

Bruno Campos

Character: Prince Naveen (voice)

Jim Cummings

Character: Ray (voice)

Michael-Leon Wooley

Character: Louis (voice)

Keith David

Character: Dr. Facilier (voice)

Jennifer Cody

Character: Charlotte (voice)

Peter Bartlett

Character: Lawrence (voice)

Jenifer Lewis

Character: Mama Odie (voice)

Oprah Winfrey

Character: Eudora (voice)

John Goodman

Character: "Big Daddy" La Bouff (voice)

Terrence Howard

Character: James (voice)

Ritchie Montgomery

Character: Reggie (voice)

Don Hall

Character: Darnell (voice)

Paul Briggs

Character: Two Fingers (voice)

Jerry Kernion

Character: Mr. Henry Fenner (voice)

Corey Burton

Character: Mr. Harvey Fenner (voice)

Elizabeth Dampier

Character: Young Tiana (voice)

Breanna Brooks

Character: Young Charlotte (voice)

Michael Colyar

Character: Buford (voice)

Emeril Lagasse

Character: Marlon the Gator (voice)

Kevin Michael Richardson

Character: Ian the Gator (voice)

Randy Newman

Character: Cousin Randy (voice)

Terence Blanchard

Character: Louis' Trumpet Playing (voice)

Mick Wingert

Character: Travis (voice)

Seth R. Williamson

Character: Prince Ralphie (voice)

Shane R. Williamson

Character: Teenage Kid (voice)

Phil Proctor

Character: Cajun Firefly (voice)

Peter Renaday

Character: Additional Voices (voice)