Amy Poehler

Character: Joy (voice)

Maya Hawke

Character: Anxiety (voice)

Kensington Tallman

Character: Riley (voice)

Liza Lapira

Character: Disgust (voice)

Tony Hale

Character: Fear (voice)

Lewis Black

Character: Anger (voice)

Phyllis Smith

Character: Sadness (voice)

Ayo Edebiri

Character: Envy (voice)

Lilimar

Character: Valentina (voice)

Grace Lu

Character: Grace (voice)

Sumayyah Nuriddin-Green

Character: Bree (voice)

Adèle Exarchopoulos

Character: Ennui (voice)

Diane Lane

Character: Mom (voice)

Kyle MacLachlan

Character: Dad (voice)

Paul Walter Hauser

Character: Embarrassment (voice)

Yvette Nicole Brown

Character: Coach Roberts (voice)

Ron Funches

Character: Bloofy (voice)

James Austin Johnson

Character: Pouchy (voice)

Yong Yea

Character: Lance Slashblade (voice)

Steve Purcell

Character: Deep Dark Secret (voice)

Dave Goelz

Character: Mind Cop Frank (voice)

Kirk R. Thatcher

Character: Foreman (voice)

Frank Oz

Character: Mind Cop Dave (voice)

Paula Pell

Character: Mom's Anger (voice)

June Squibb

Character: Nostalgia (voice)

Pete Docter

Character: Dad's Anger (voice)

Paula Poundstone

Character: Forgetter Paula (voice)

John Ratzenberger

Character: Fritz (voice)

Sarayu Blue

Character: Margie (voice)

Flea

Character: Jake (voice)

Bobby Moynihan

Character: Forgetter Bobby (voice)

Kendall Coyne Schofield

Character: Hockey Announcer (voice)