Meg Ryan

Character: Eve Mozell Marks

Diane Keaton

Character: Georgia Mozell

Lisa Kudrow

Character: Maddy Mozell

Walter Matthau

Character: Lou Mozell

Adam Arkin

Character: Joe Marks

Jesse James

Character: Jesse Marks

Shaun Duke

Character: Dr. Omar Kunundar

Ann Bortolotti

Character: Ogmed Kunundar

Cloris Leachman

Character: Pat Mozell

Maree Cheatham

Character: Angie

Myndy Crist

Character: Dr. Kelly

Edie McClurg

Character: Esther

Tracee Ellis Ross

Character: Kim

Libby Hudson

Character: Georgia's Assistant (Libby)

Celia Weston

Character: Madge Turner

Stephanie Ittleson

Character: Victoria

Charles Matthau

Character: Young Lou

Paige Wolfe

Character: Six-Year-Old Eve

Katie Stratton

Character: Twelve-Year-Old Georgia

Talia-Lynn Prairie

Character: Four-Year-Old Maddy

Ethan Dampf

Character: Four-Year-Old Jesse Marks

Bob Kirsh

Character: Nixon Library Representative

Kristina Dorn

Character: Young Pat

Venessia Valentino

Character: Nurse at Mesh Window

R.A. Buck

Character: Gay Man

Phil Levesque

Character: Gay Man

Mary Beth Pape

Character: Mother at Party

Catherine Paolone

Character: Doctor

Carol Mansell

Character: Woman Who Recognizes Maddy

Lucky Vanous

Character: Montana Dude

Bill Robinson

Character: Doctor on Soap

Jaffe Cohen

Character: Sub-Editor

Johnathan Cale

Character: Hairdresser

Janet Dey

Character: Event Attendee (uncredited)