Garry Shandling

Character: Harold Anderson

Annette Bening

Character: Susan Anderson

John Goodman

Character: Roland Jones

Greg Kinnear

Character: Perry Gordon

Ben Kingsley

Character: Graydon

Judy Greer

Character: Rebecca

Danny Zorn

Character: Randy

Harmony Smith

Character: Rita

Richard Jenkins

Character: Don Fisk

Linda Fiorentino

Character: Helen Gordon

Caroline Aaron

Character: Nadine Jones

Janeane Garofalo

Character: Nervous Woman

Octavia Spencer

Character: Baby Nurse

Nora Dunn

Character: Madeline

Cricky Long

Character: Janice

Camryn Manheim

Character: Alison

Ann Cusack

Character: Liz

Jane Lynch

Character: Doreen

Richard Minchenberg

Character: Dr. Weitzman

Drinda Lalumia

Character: Drunken Lady

J.C. MacKenzie

Character: John

Willie Garson

Character: Brett

Marjorie Lovett

Character: Neighbor Woman

Bil Dwyer

Character: Husband

Alexander Lyras

Character: Male AA

Stacey Travis

Character: Woman

Brian Tee

Character: Alien (uncredited)

Sarah Silverman

Character: Woman on plane

Phill Lewis

Character: Other MD

Rick Avery

Character: Airlane Passenger (uncredited)

Tori Bridges

Character: Airport Clerk (uncredited)

James Hunter

Character: Alien Student (uncredited)