Robert Downey Jr.

Character: Sherlock Holmes

Jude Law

Character: Dr. John Watson

Rachel McAdams

Character: Irene Adler

Mark Strong

Character: Lord Henry Blackwood

Eddie Marsan

Character: Inspector Lestrade

Robert Maillet

Character: Dredger

Geraldine James

Character: Mrs. Hudson

Kelly Reilly

Character: Mary Morstan

William Houston

Character: Constable Clark

Hans Matheson

Character: Lord Coward

James Fox

Character: Sir Thomas Rotheram

William Hope

Character: Ambassador Standish

Clive Russell

Character: Captain Tanner

Oran Gurel

Character: Reordan

David Garrick

Character: McMurdo

Ky Discala

Character: Maid

Andrew Brooke

Character: Guard Captain

Tom Watt

Character: Carriage Driver

John Kearney

Character: Carriage Driver

Sebastian Abineri

Character: Coach Driver

Jonathan Gabriel Robbins

Character: Guard

James A. Stephens

Character: Captain Philips

Terence Taplin

Character: Groundskeeper

Bronagh Gallagher

Character: Palm Reader

Ed Tolputt

Character: Anonymous Man

Joe Egan

Character: Big Man

Jefferson Hall

Character: Young Guard

Miles Jupp

Character: Waiter

Marn Davies

Character: Police Officer

Andrew Greenough

Character: Prison Guard

Ned Dennehy

Character: Man with Roses

Martin Ewens

Character: Removable Man

Amanda Grace Johnson

Character: Young Woman Sacrifice

James Greene

Character: Governor

David Emmings

Character: Grave Policeman

Ben Cartwright

Character: Grave Policeman

Chris Sunley

Character: Grave Policeman

Michael Jenn

Character: Preacher

Timothy O'Hara

Character: Porter / Smith

Guy Williams

Character: Golden Dawn Envoy

Peter Miles

Character: Thug

Rocco Ritchie

Character: Boy in the Street (uncredited)