Lea Thompson

Character: Beverly Switzler

Jeffrey Jones

Character: Dr. Walter Jenning

Tim Robbins

Character: Phil Blumburtt

Ed Gale

Character: Howard T. Duck

Chip Zien

Character: Howard T. Duck (voice)

Tim Rose

Character: Howard T. Duck

Steve Sleap

Character: Howard T. Duck

Peter Baird

Character: Howard T. Duck

Mary Wells

Character: Howard T. Duck

Lisa Sturz

Character: Howard T. Duck

Jordan Prentice

Character: Howard T. Duck

Paul Guilfoyle

Character: Lieutenant Welker

Liz Sagal

Character: Ronette

Dominique Davalos

Character: Cal

Holly Robinson Peete

Character: K.C.

Tommy Swerdlow

Character: Ginger Moss

Richard Edson

Character: Ritchie

Miles Chapin

Character: Carter

Richard McGonagle

Character: First Cop

Virginia Capers

Character: Coramae

Debbie Lee Carrington

Character: Additional Ducks (voice)

Jorli McLain

Character: Waitress

Miguel Sandoval

Character: Club Owner

Sheldon Feldner

Character: Hot Tub Spa Owner

Lee Anthony

Character: Grossbach

Paul Comi

Character: Dr. Chapin

Maureen Coyne

Character: Teacher

James Lashly

Character: State Trooper

Tom Parker

Character: Steve Kanelli

Ed Holmes

Character: TV Duck Hunter

David Paymer

Character: Larry, Scientist

William Hall

Character: Hanson

Denny Delk

Character: Sergeant

Martin Ganapoler

Character: First Trucker

Tom Rayhall

Character: Second Trucker

Gary Littlejohn

Character: Third Trucker

Thomas Dolby

Character: Bartender in Rock Club

Kristopher Logan

Character: Punk

Reed Kirk Rahlmann

Character: Bender

John Fleck

Character: Pimples

William McCoy

Character: Skin Head

Steven Kravitz

Character: Lover Boy

Anne Tofflemire

Character: Lover Girl

Marcia Banks

Character: Mama Biker

Nancy Fish

Character: Bag Lady

Monty Hoffman

Character: Club Bouncer

Ted Kurtz

Character: Kirby

Wood Moy

Character: Chef

Wanda McCaddon

Character: Hostess

James Brady

Character: First Tour Guide

Carol McElheney

Character: Screaming Woman

Jeanne Lauren

Character: Bear

Richard Kiley

Character: The Cosmos (voice)

Mel Blanc

Character: Daffy Duck (voice) (archive sound)