Danny Trejo

Character: Machete Cortez

Mel Gibson

Character: Luther Voz

Demián Bichir

Character: Mendez

Amber Heard

Character: Blanca Vasquez / Miss San Antonio

Michelle Rodriguez

Character: Luz

Sofía Vergara

Character: Desdemona

Charlie Sheen

Character: Mr. President (credited as Carlos Estévez)

Jessica Alba

Character: Sartana Rivera

Lady Gaga

Character: La Camaleon

Alexa PenaVega

Character: KillJoy

Vanessa Hudgens

Character: Cereza Desdemona

Tom Savini

Character: Osiris Amanpour

Cuba Gooding Jr.

Character: El Camaleon

Antonio Banderas

Character: El Camaleon

Walton Goggins

Character: El Camaleon

William Sadler

Character: Sheriff Doakes

Marko Zaror

Character: Zaror

Julio Oscar Mechoso

Character: Chepo

Billy Blair

Character: Billy

Samuel Davis

Character: Clebourne

Felix Sabates

Character: Doc Felix

Electra Avellan

Character: Nurse Mona

Elise Avellan

Character: Nurse Lisa

Marci Madison

Character: Nurse Fine

Callie Hernandez

Character: Space Babe

Alejandro Antonio

Character: Boss of Mendez

Crystal Martinez

Character: Wife of Mendez

Corey Burton

Character: Trailer Voice Guy (voice)

Elon Musk

Character: Elon Musk

Emmy Robbin

Character: Pris

Jason Christopher

Character: Lieutenant Brass

Sam Medina

Character: Cartel Leader

J.J. Perry

Character: Voz's Henchman (uncredited)

Alexander Rodnyansky

Character: Radio Guest (uncredited)

Vincent Fuentes

Character: Cabrito Cook

Elle LaMont

Character: Dollface

Jorge A. Jimenez

Character: Dying Cartel Guy