Matthew McConaughey

Character: Ed 'Eddie' Pekurny

Woody Harrelson

Character: Ray Pekurny

Sally Kirkland

Character: Jeanette

Jenna Elfman

Character: Shari

Martin Landau

Character: Al

Ellen DeGeneres

Character: Cynthia Topping

Rob Reiner

Character: Mr. Whitaker

Dennis Hopper

Character: Henry 'Hank' Pekurny

Elizabeth Hurley

Character: Jill

Adam Goldberg

Character: John

Viveka Davis

Character: Marcia

Clint Howard

Character: Ken

Geoffrey Blake

Character: Keith

Gail Boggs

Character: Wife

Jenna Byrne

Character: Felicia

Greg Sestero

Character: Roach

RuPaul

Character: RuPaul

Merrin Dungey

Character: Ms. Seaver

Ian Gomez

Character: McIlvaine

Gavin Grazer

Character: Clint

Chris Hogan

Character: Paul

Arianna Huffington

Character: Panel Member

Larry Jenkins

Character: Husband

Wendle Josepher

Character: Rita

Scott LaRose

Character: Desipio

John Livingston

Character: Terry

Mitzi McCall

Character: Fig Lady

Jim Meskimen

Character: Dr. Geller

Don Most

Character: Benson

Rick Overton

Character: Barry

James Ritz

Character: Tad

Rusty Schwimmer

Character: Alice

Steven Shenbaum

Character: Jack

Gedde Watanabe

Character: Greg

Steve Kehela

Character: Reporter

Googy Gress

Character: Reporter

Jo McGinley

Character: Tracy

John Pirruccello

Character: Kevin

Charles Arthur Berg

Character: Party Goer

Anthony Jensen

Character: Party Goer

Sommer Garcia

Character: College Girl

Jennifer Elise Cox

Character: College Girl

Alexandra Holden

Character: College Girl

Mark Wheeler

Character: Bartender

Anna Karin

Character: Snapple Girl

George Plimpton

Character: Panel Member

Michael Moore

Character: Panel Member

Merrill Markoe

Character: Panel Member

Bill Maher

Character: Bill Maher

Jay Leno

Character: Jay Leno

Sonia Bhalla

Character: Ticket Taker

Joe Bellan

Character: Lou

Diane Amos

Character: Autograph Mom

Wade Robson

Character: Teenage Boy

Andy Arness

Character: Groupie (uncredited)

Cyndi Pass

Character: Cassie

J. Anthony Pena

Character: Con-Ed Guy (uncredited)

Carl Solomon

Character: Ed Groupie (uncredited)

Bob Sarlatte

Character: Motorcycle Cop

T.J. Thyne

Character: Frat Gut