Peter Weller

Character: Buckaroo Banzai

John Lithgow

Character: Lord John Whorfin

Ellen Barkin

Character: Penny Priddy

Jeff Goldblum

Character: New Jersey

Christopher Lloyd

Character: John Bigboote

Lewis Smith

Character: Perfect Tommy

Rosalind Cash

Character: John Emdall

Robert Ito

Character: Professor Hikita

Pepe Serna

Character: Reno Nevada

Ronald Lacey

Character: President Widmark

Matt Clark

Character: Secretary of Defense

Clancy Brown

Character: Rawhide

William Traylor

Character: General Catburd

Carl Lumbly

Character: John Parker

Vincent Schiavelli

Character: John O'Connor

Dan Hedaya

Character: John Gomez

Mariclare Costello

Character: Senator Cunningham

Bill Henderson

Character: Casper Lindley

Damon Hines

Character: Scooter Lindley

Billy Vera

Character: Pinky Carruthers

Laura Harrington

Character: Mrs. Johnson

Michael Santoro

Character: Billy Travers

Jonathan Banks

Character: Lizardo Hospital Guard

Robert Gray

Character: Radar Blazer

Gary Bisig

Character: Radar Blazer

Kent Perkins

Character: Mission Control

John Ashton

Character: Highway Patrolman

Ken Magee

Character: Duck Hunter Burt

James Keane

Character: Duck Hunter Bubba

Yakov Smirnoff

Character: National Security Advisor

Leonard Gaines

Character: Artie Duncan

Francine Lembi

Character: TV Anchorwoman

John Walter Davis

Character: Star Surgeon

Read Morgan

Character: Exhibitor

James Rosin

Character: John Yaya

Sam Minsky

Character: Kolodny Brother