Rachel McAdams

Character: Lisa Reisert

Cillian Murphy

Character: Jackson Rippner

Brian Cox

Character: Joe Reisert

Jayma Mays

Character: Cynthia

Jack Scalia

Character: Dep. Sec. Charles Keefe

Robert Pine

Character: Bob Taylor

Terry Press

Character: Marianne Taylor

Brittany Oaks

Character: Rebecca

Laura Johnson

Character: Blonde Woman

Max Kasch

Character: Headphone Kid

Kyle Gallner

Character: Headphone Kid's Brother

Angela Paton

Character: Nice Lady

Loren Lester

Character: Irate Passenger

Suzie Plakson

Character: Senior Flight Attendant

Monica McSwain

Character: Junior Flight Attendant

Dane Farwell

Character: Hit Man at Dad's House

Beth Toussaint

Character: Lydia Keefe

Adam Gobble

Character: Keefe's Son

Megan Crawford

Character: Keefe's Daughter

Carl Gilliard

Character: Taxi Driver

Mary Kathleen Gordon

Character: Airline Representative

Philip Pavel

Character: Dallas Ticket Agent

Amber Mead

Character: Dallas Ticket Agent

Dey Young

Character: Dallas Gate Agent

Jeanine Jackson

Character: Passenger with Iced Mocha

Carmen Gloria Pérez

Character: Airline Passenger

Colby Donaldson

Character: Keefe's Head Bodyguard

Jennie Baek

Character: Keefe's Assistant

Amanda Young

Character: Flight Attendant

Jim Lemley

Character: Man on Fishing Boat

Jenny Wade

Character: Coffee Shop Girl

Wes Craven

Character: Airline Passenger (uncredited)

Marc Macaulay

Character: Coast Guard Officer

Mark Cotone

Character: Man on Fishing Boat

Chris Bender

Character: Airline Passenger (uncredited)

Marianne Maddalena

Character: Flight Passenger (uncredited)