Gwyneth Paltrow

Character: Donna Jensen

Christina Applegate

Character: Christine Montgomery

Mark Ruffalo

Character: Ted Stewart

Candice Bergen

Character: Sally Weston

Joshua Malina

Character: Randy Jones

Mike Myers

Character: John Witney

Kelly Preston

Character: Sherry

Stacey Dash

Character: Angela Samona

Rob Lowe

Character: Co-Pilot Steve Bench

Marc Blucas

Character: Tommy Boulay

Frederick Coffin

Character: Mr. Stewart

Jon Polito

Character: Roy Roby

Concetta Tomei

Character: Mrs. Stewart

Robyn Peterson

Character: Donna's Mom

Nadia Dajani

Character: Paige

John Francis Daley

Character: Rodney

Priscilla Inga Taylor

Character: Janette

Matt Roth

Character: Greg

DonnaMarie Recco

Character: Tammy

Daniel Raymont

Character: British Man

Connie Sawyer

Character: Grandma Stewart

David Hayward

Character: Pete

Chelsey Cole

Character: Donna - 6 Years Old

Troy Evans

Character: Customer

Merrilee McCommas

Character: June

George Kennedy

Character: Passenger Requesting Vodka (uncredited)

Candice T. Cain

Character: CDG Passenger (uncredited)

Valentin Siroon

Character: Flight Attendant Trainee (uncredited)

Jessica Capshaw

Character: Royalty International Flight Attendant (uncredited)

Mary McNeal

Character: Ted's Study Partner Mary

Stephanie Miller

Character: TV Interviewer

Susan Mosher

Character: Senior Flight Attendant

Victoria Garcia-Kelleher

Character: Clerk #1 (uncredited)

Stephen Tobolowsky

Character: Frank Thomas (uncredited)

Anastacia Spiegel

Character: Runway Model at Airport (uncredited)

Amanda Wycoff

Character: Flight Attendant Trainee (uncredited)

Dawn-Marie Whelan

Character: Flight Attendant Trainee Anne (uncredited)

Jeff Yagher

Character: Ghost Rider

Greg Bronson

Character: Fashion Photographer (uncredited)

Roark Critchlow

Character: Tennis Pro (uncredited)

Chad Everett

Character: Jack Weston (uncredited)

Wayne Federman

Character: Whiskey Sour Man (uncredited)

Clarinda Ross

Character: Diaper Woman (uncredited)

Jackie Zane

Character: Passenger in Terminal (uncredited)