George C. Scott

Character: Lt. William 'Bill' Kinderman

Ed Flanders

Character: Father Joseph Kevin Dyer

Brad Dourif

Character: James Venamun / The Gemini Killer

Jason Miller

Character: Father Damien Karras / Patient X

Nicol Williamson

Character: Father Morning

Scott Wilson

Character: Dr. Temple

Nancy Fish

Character: Nurse Allerton

George DiCenzo

Character: Stedman

Don Gordon

Character: Ryan

Lee Richardson

Character: University President

Grand L. Bush

Character: Sergeant Atkins

Mary Jackson

Character: Mrs. Clelia

Viveca Lindfors

Character: Nurse X

Ken Lerner

Character: Dr. Freedman

Tracy Thorne

Character: Nurse Keating

Barbara Baxley

Character: Shirley

Zohra Lampert

Character: Mary Kinderman

Harry Carey, Jr.

Character: Father Kanavan

Sherrie Wills

Character: Julie Kinderman

Edward Lynch

Character: Patient A

Clifford David

Character: Dr. Bruno

Alex Zuckerman

Character: Korner Boy

Lois Foraker

Character: Nurse Merrin

Tyra Ferrell

Character: Nurse Blaine

James Burgess

Character: Thomas Kintry

Kevin Corrigan

Character: Altar Boy

Peggy Alston

Character: Mrs. Kintry

John Durkin

Character: Elderly Jesuit

Bobby Deren

Character: Nurse Bierce

Jan Neuberger

Character: Alice

Alexis Chieffet

Character: Counter Attendant

Debra Port

Character: Waitress

Walt MacPherson

Character: Police Sergeant

David Dwyer

Character: Second Police Officer

Danny Epper

Character: Police Driver

William Preston

Character: Old Man in Wheelchair

Chuck Kinlaw

Character: Attendant

Demetrios Pappageorge

Character: Casperelii

Nina Hansen

Character: Little Old Lady

Samuel L. Jackson

Character: Dream Blind Man

Shane Wexel

Character: First Dream Boy (uncredited)

Ryan Paul Amick

Character: Second Dream Boy (uncredited)

John Coe

Character: Old Man in Dream (uncredited)

Jodi Long

Character: First Dream Woman (uncredited)

Kathy Gerber

Character: Second Dream Woman (uncredited)

Jan Smook

Character: Radio Man (uncredited)

Amelia Campbell

Character: Young Girl in Dream (uncredited)

Cherie Baron

Character: Nurse

Larry King

Character: Larry King

C. Everett Koop

Character: Everett Koop

Patrick Ewing

Character: Angel of Death

Clinton Brandhagen

Character: Young Boy in Dream (uncredited)

Michael Criscuolo

Character: Mental Patient (uncredited)

Cindy Cullom

Character: Nurse (uncredited)

Colleen Dewhurst

Character: Satan (voice) (uncredited)

Fabio

Character: Angel (uncredited)

Randy Aaron Fink

Character: Student (uncredited)

Jeff Henry

Character: Angel (uncredited)

Patt Noday

Character: Hospital Ward Priest (uncredited) (unconfirmed)

Manley Pope

Character: Angel (uncredited)

John Thompson

Character: John Thompson - Georgetown Hoyas Basketball Coach (uncredited)

Michael Tove

Character: Man in Purgatory (uncredited)

Brad Waller

Character: Asylum Inmate (uncredited)

Gary Wheeler

Character: Crime Photographer (uncredited)

Teresa Wright

Character: Penitent (uncredited)

Charles Edwin Powell

Character: Patient X Possessed