Andy Samberg

Character: Ham III (voice)

Cheryl Hines

Character: Luna (voice)

Jeff Daniels

Character: Zartog (voice)

Patrick Warburton

Character: Titan (voice)

Kristin Chenoweth

Character: Kilowatt (voice)

Kenan Thompson

Character: Ringmaster (voice)

Zack Shada

Character: Comet / Nava Boy (voice)

Carlos Alazraqui

Character: Houston (voice)

Omid Abtahi

Character: Dr. Jagu (voice)

Patrick Breen

Character: Dr. Bob (voice)

Jane Lynch

Character: Dr. Poole (voice)

Kath Soucie

Character: Dr. Smothers (voice)

Stanley Tucci

Character: Senator (voice)

Wally Wingert

Character: Splork / Infinity Probe / Pappy Ham (voice)

Jessica Gee-George

Character: Ship Voice / Infinity Probe / Additional Voices (voice)

Tom Kenny

Character: Newsreel (voice)

Jason Harris

Character: Guard (voice)

Jess Harnell

Character: Additional Voices (voice)

Ellie Harvie

Character: Additional Voices (voice)

Caitlin McKenna

Character: Additional Voices (voice)