Robert De Niro

Character: Don Lino (voice)

Martin Scorsese

Character: Sykes (voice)

Will Smith

Character: Oscar (voice)

Renée Zellweger

Character: Angie (voice)

Jack Black

Character: Lenny (voice)

Ziggy Marley

Character: Ernie (voice)

Doug E. Doug

Character: Bernie (voice)

Shelley Morrison

Character: Mrs. Sanchez (voice)

David Soren

Character: Shrimp (voice)

David P. Smith

Character: Crazy Joe (voice)