Donald Sutherland

Character: Matthew Bennell

Brooke Adams

Character: Elizabeth Driscoll

Leonard Nimoy

Character: Dr. David Kibner

Jeff Goldblum

Character: Jack Bellicec

Veronica Cartwright

Character: Nancy Bellicec

Art Hindle

Character: Dr. Geoffrey Howell

Lelia Goldoni

Character: Katherine Hendley

Kevin McCarthy

Character: Running Man

Don Siegel

Character: Taxi Driver

Tom Luddy

Character: Ted Hendley

Stan Ritchie

Character: Stan

David Fisher

Character: Mr. Gianni

Tom Dahlgren

Character: Detective

Garry Goodrow

Character: Dr. Boccardo

Jerry Walter

Character: Restaurant Owner

Maurice Argent

Character: Chef

Sam Conti

Character: Street Barker

Wood Moy

Character: Mr. Tong

R. Wong

Character: Mrs. Tong

Rose Kaufman

Character: Outraged Woman

Joe Bellan

Character: Harry

Sam Hiona

Character: Policeman #1

Lee McVeigh

Character: Policeman #2

Al Nalbandian

Character: Rodent Man

Lee Mines

Character: School Teacher

Robert Duvall

Character: Priest on Swing (uncredited)

Michael Chapman

Character: Health Dept. Floor Cleaner (uncredited)

Philip Kaufman

Character: City Official on Phone (uncredited) (voice)

Al Perez

Character: PG&E Man (uncredited)

Jeff Scheftel

Character: Pod Person at Party (uncredited)

Kevin Harris

Character: Dr. of pods (uncredited)