Eddie Murphy

Character: Sherman Klump / Buddy Love / Granny Klump / Mama Klump / Papa Klump / Young Papa Klump / Ernie Klump / Lance Perkins

Janet Jackson

Character: Denise

Larry Miller

Character: Dean Richmond

John Ales

Character: Jason

Richard Gant

Character: Denise's Father

Anna Maria Horsford

Character: Denise's Mother

Melinda McGraw

Character: Leanne Guilford

Jamal Mixon

Character: Ernie Klump, Jr.

Gabriel Williams

Character: Issac

Chris Elliott

Character: Restaurant Manager

Duffy Taylor

Character: Restaurant Trainee

Earl Boen

Character: Dr. Knoll

Nikki Cox

Character: Bright Student

Freda Payne

Character: Claudine

Sylvester Jenkins

Character: Old Willie

Wanda Sykes

Character: Chantal

George King

Character: Stripper

Charles Walker

Character: Preacher

Enya Flack

Character: Bridesmaid

Rainell Saunders

Character: Bridesmaid

Andrea C. Robinson

Character: Party Guest / Bridesmaid

Kym Whitley

Character: Party Guest

Selma Stern

Character: Mrs. Dudikoff

Julia Schultz

Character: Receptionist

Barry W. Blaustein

Character: Man in Bathroom

David Sheffield

Character: Man in Bathroom

Ralph Drischell

Character: Zeke

Myles Mason

Character: Baby Buddy

Jeffrey Michael Freeman

Character: Baby Buddy

Maurice Colquitt

Character: Baby Buddy

Bill Applebaum

Character: Boardroom Member

Harry S. Murphy

Character: Boardroom Member

Tom Jourden

Character: Guy in Elevator

Shawnette Heard

Character: Dancer

Kelly Konno

Character: Dancer

Laurie Sposit

Character: Dancer

Nadine Ellis

Character: Dancer

Kevin Michael Mondane

Character: Buddy at 15

Viola Kates Stimpson

Character: Sweet Old Lady with Dog

Naomi Morales

Character: Buxom Student

Kente Scott

Character: Fraternity Student

Justin Urich

Character: Lecture Student

Sonya Eddy

Character: Heavyset Woman

James D. Brubaker

Character: Krusty Reporter

Richie Palmer

Character: Cab Driver

Charles Napier

Character: Four Star General

Steve Kehela

Character: Scientist

Miguel A. Núñez Jr.

Character: Scientist

Richard Saxton

Character: Newscaster

Peter Segal

Character: Scared Popcorn Man

William Kerr

Character: Scared Popcorn Man

Michael Ewing

Character: Scared Hot Dog Vendor

Nikki Segal

Character: Scared Little Girl

Kathleen Freeman

Character: Denise's Nosy Neighbor (uncredited)