Bill Pullman

Character: George Bailey

Penelope Ann Miller

Character: Mary Hatch Bailey

Nathan Lane

Character: Clarence

Martin Landau

Character: Pa Bailey / Mr. Potter

Sally Field

Character: Mrs. Bailey / Narrator

Joe Mantegna

Character: Joseph / Nick

Christian Slater

Character: Harry Bailey / Sam Wainwright

Jerry Van Dyke

Character: Uncle Billy

Robert Guillaume

Character: Mr. Gower

Carol Kane

Character: Cousin Tilly / Mrs. Hatch

Bronson Pinchot

Character: Mr. Carter

Dan Lauria

Character: Bert

Craig Sheffer

Character: Ernie Bishop / Ed / Bridgekeeper

Armelia McQueen

Character: Mrs. Thompson

Ryan Slater

Character: Young George Bailey / Peter Bailey

Tina Majorino

Character: Janie Bailey

Myles Jeffrey

Character: Tommy Bailey

Mae Whitman

Character: Zuzu Bailey

Casey Kasem

Character: Radio Announcer