Martin Sheen

Character: Dr. Austin Raybourne

Liza Weil

Character: Sophie Mathers

Stacy Keach

Character: Will Sokolowski

Dot-Marie Jones

Character: Sharon Weymouth

June Squibb

Character: Gladys Sokolowski

Jon Lovitz

Character: Mayor of Cleveland

Santino Fontana

Character: Gary Lucarelli

Dennis Haysbert

Character: Marty Anderson

Loretta Devine

Character: Joy Morris

Jeff Hiller

Character: Graham Hargreaves

Rory O'Malley

Character: Hugh Robinson

Vanessa Burghardt

Character: Hannah Mathers

Rob Mayes

Character: Frank

Esther Povitsky

Character: Sara Levine

Stephon Fuller

Character: Sheldon White

Mark L. Walberg

Character: Host Tom L. Hanks

Joette Waters

Character: Stacey

Logan Soland

Character: Bobby

Yvette Yates Redick

Character: Maria Toddy

Benjamin Steinhauser

Character: Charlie Toddy

Lissy Gulick

Character: Wanita

David Towne

Character: Josh

Rich Williams

Character: Lou

Heidi Lewandowski

Character: Bonnie

Bryant Carroll

Character: Butcher