Will Ferrell

Character: Harold Crick

Maggie Gyllenhaal

Character: Ana Pascal

Dustin Hoffman

Character: Professor Jules Hilbert

Emma Thompson

Character: Karen Eiffel

Queen Latifah

Character: Penny Escher

Tony Hale

Character: Dave

William Dick

Character: IRS Co-Worker #1

Guy Massey

Character: IRS Co-Worker #2

Martha Espinoza

Character: IRS Co-Worker #3

T.J. Jagodowski

Character: IRS Co-Worker #4

Peter Grosz

Character: IRS Co-Worker #5

Tonray Ho

Character: IRS Co-Worker #6

Herb Lichtenstein

Character: IRS Co-Worker #7

Stacey Elaine Jackson

Character: IRS Co-Worker #8

Ricky Adams

Character: Young Boy

Christian Stolte

Character: Young Boy's Father

Denise Hughes

Character: Kronecker Bus Driver

Peggy Roeder

Character: Polish Woman

Danny Rhodes

Character: Bakery Employee #1

Linara Washington

Character: Bakery Employee #2

Helen Young

Character: Bakery Customer #1

David Pompeii

Character: Bakery Customer #2

David Wiegers

Character: Bakery Customer #3

Jarrett Sleeper

Character: Bakery Customer #4

Larry Neumann Jr.

Character: Homeless Man

John Mohrlein

Character: Man with Hose

Tom Hulce

Character: Dr. Cayly

Bruce Jarchow

Character: Commuter

Linda Hunt

Character: Dr. Mittag-Leffler

Kristin Chenoweth

Character: Book Channel Host

Bradley Mott

Character: Large Man on Bus

John M. Watson Sr.

Character: TV Author

Karen Lloyd

Character: Customer with Tan

Keith Kupferer

Character: Demolition Foreman

Danny McCarthy

Character: Demolition Crew #1

Tab Baker

Character: Demolition Crew #2

Mark Buettner

Character: Claw Operator

Christian Young

Character: ER Doctor #1

Ray Kurut

Character: ER Doctor #2

Michael Cook

Character: ER Doctor #3

Arraon Skippa Hixson

Character: Young Man Patient

Bryan Kelly

Character: ER Orderly

Whitney Sneed

Character: ER Nurse #1

Celeste Pechous

Character: ER Nurse #2

Cheryl Lynn Bruce

Character: Head ER Nurse

Chet Dubowski

Character: Man in Tweed

Ora Jones

Character: Banneker Press Receptionist

Jordan Keller

Character: Grocer

Jordan Teplitz

Character: Old Man on Phone

Ricardo Gutierrez

Character: Bus Company Manager

James Mazza

Character: Irritated Man on Bus

Oscar Roxas

Character: Another Man on Bus

Nadirah Bost

Character: Accident Witness

Sandra Marquez

Character: Accident Witness

Lacy Katherine Campbell

Character: Accident Witness

Will Clinger

Character: Accident Witness

Al Samuels

Character: Accident Witness

Frank Caeti

Character: Accident Witness

Andrew Rothenberg

Character: Doctor Mercator

Rengin Altay

Character: Nurse

Lucinda Kemp

Character: Bus Operator #1

Donna Watkins

Character: Bus Operator #2

Julia Heron

Character: Animal Footage Voice Over (voice)

Lora Cain

Character: Animal Footage Voice Over (voice)

Bob Papenbrook

Character: Animal Footage Voice Over (voice)

Mike McColl

Character: Animal Footage Voice Over (voice)

Nathan Adloff

Character: Bakery Patron (uncredited)

Sia A. Moody

Character: Nurse #3 (uncredited)

Eli Goodman

Character: Augustus Chatman (uncredited)

Edy Cullen

Character: Business Women (uncredited)

Tim Krueger

Character: Business Man (uncredited)