Ryan Reynolds

Character: Gary / Gavin / Gabriel

Melissa McCarthy

Character: Margaret / Melissa / Mary

Hope Davis

Character: Sarah / Susan / Sierra

Elle Fanning

Character: Noelle

David Denman

Character: Parole Officer/ Agitated Man

Octavia Spencer

Character: Streetwalker

Ben Falcone

Character: Ben Falcone

Dahlia Salem

Character: Dahlia Salem

John Gatins

Character: John Gatins

Lorene Scafaria

Character: Game Night Guest

Rawson Marshall Thurber

Character: Game Night Guest

Jim Rash

Character: Game Night Guest