Zach Braff

Character: Tom Reilly

Amanda Peet

Character: Sofia Kowalski

Jason Bateman

Character: Chip Sanders

Charles Grodin

Character: Bob Kowalski

Mia Farrow

Character: Amelia Kowalski

Lucian Maisel

Character: Wesley

Donal Logue

Character: Don Wollebin

Amy Poehler

Character: Carol Lane

Fred Armisen

Character: Manny

Bob Stephenson

Character: Doug

Yaffit Hallely

Character: Woman

Josh Charles

Character: Forrest Mead

Marin Hinkle

Character: Karen

Yul Vazquez

Character: Paco

Michael Lawson

Character: Busboy

Paul Rudd

Character: Leon

Nick Grodin

Character: Summers

Robert John Burke

Character: Colonel

Romany Malco

Character: Doctor Hakim Oliver

Carole Troll

Character: Nurse

Sarah Jenkins

Character: Nancy

Edmund Lyndeck

Character: Mr. Hordhaus

Amy Adams

Character: Abby March

Caitlin Miller

Character: Lisbeth

Lauren Weedman

Character: Alice

Michael Cumpsty

Character: Jack Connor

Katie Barrett

Character: Executive

John Benjamin Hickey

Character: Wesley's Dad

Declan Patrick Schenck

Character: Baby Oliver (2 Months)

Brayden Julian Schenck

Character: Baby Oliver (2 Months)

Connor Grace

Character: Baby Oliver (6 Months)

Frank Girardeau

Character: Fire Inspector

Ian Hyland

Character: Steve

Tarina Pouncy

Character: Ticket Agent

Cyrus Hernstadt

Character: Kid with Toy Car

Sig Libowitz

Character: Hassidic Guy

Sheila K. Adams

Character: Steve's Mom

Edwin Lopez

Character: Wheelchair Basketball Player #1

Eddie McGee

Character: Wheelchair Basketball Player #2

Shevy Gutierrez

Character: Lower East Sider (uncredited)

Ismaelpeter Casillas Nelson

Character: Kid at Birthday Party (uncredited)

Laurent Vernin

Character: Tom Reilly (voice) (uncredited)