Adrien Brody

Character: Leonard Chess

Jeffrey Wright

Character: Muddy Waters

Gabrielle Union

Character: Geneva Wade

Columbus Short

Character: Little Walter

Cedric the Entertainer

Character: Willie Dixon

Emmanuelle Chriqui

Character: Revetta Chess

Eamonn Walker

Character: Howlin' Wolf

Tammy Blanchard

Character: Isabelle Allen

Eric Bogosian

Character: Alan Freed

Norman Reedus

Character: Chess Engineer

Yasiin Bey

Character: Chuck Berry

Beyoncé

Character: Etta James

Josh Alscher

Character: Mick Jagger

Tim Bellow

Character: Man in the Caddy

Tony Bentley

Character: Lomax

Marc Bonan

Character: Keith Richards

Douglas Crosby

Character: Policeman (Little Walter beating)

Dexter Darden

Character: Geneva's Teenage Son

Veronika Dash

Character: Blonde Girl

Sean Shyboy Davis

Character: Toothless Hillbilly Little Walter

Eshaya Draper

Character: Charles Waters

Christopher Durham

Character: Policeman (with Chuck Berry)

Shiloh Fernandez

Character: Phil Chess

Jill Flint

Character: Shelly Feder

Erik Frandsen

Character: Engineer - Present Day

Gano Grills

Character: Slick Pimp

Suzette Gunn

Character: Minnie Ripperton

Jordan Haynes

Character: Pot Strong

William Hill

Character: Policeman (with the Stones)

Mike Hodge

Character: Bartender

Tyler Humphrey

Character: Muddy - Age 6

Osas Ighodaro

Character: Maid

Kevin Jackson

Character: Mysterious Black Man

Albert Jones

Character: Hubert Sumlin

Rayan Lawrence

Character: Harmonica Player

Chyna Layne

Character: Pot's Girlfriend Juanita

Kevin Mambo

Character: Jimmy Rogers

Aaron Muñoz

Character: Manager

Wade Mylius

Character: Bouncer

Rebecca Pappa

Character: Another Blonde

Jonathan Earl Peck

Character: Man Who Rolled 7

Q-Tip

Character: Hip Hop Artist

Ginnie Randall

Character: Muddy's Grandmother

Ashlee Ray

Character: Muddy's Floozy #1

Jake Robards

Character: Producer - Present Day

Jay O. Sanders

Character: Mr. Feder

Samuel Smith

Character: Guitarist

Valence Thomas

Character: James Cotton

Carmen Ziina Vasquez

Character: Muddy's Floozy #2

Isiah Whitlock Jr.

Character: Mississippi DJ

Kade Alexie

Character: Guitar Player (uncredited)

Kandé Amadou

Character: Little Walter's Girlfriend (uncredited)

Angelina Aucello

Character: Teenybopper (uncredited)

Lawrence P. Beron

Character: Overseer (uncredited)

Ryan Curtis

Character: Picnic Boyfriend (uncredited)

Vincent D'Onofrio

Character: Mississippi DJ (uncredited)

Seth Donavan

Character: Chuck Berry Concertgoer (uncredited)

John Farrer

Character: Etta's Violinist (uncredited)

Doug W. Goldman

Character: Etta's Trumpet Player (uncredited)

Evan Hart

Character: Young Lover (uncredited)

Tiffany M. Johnson

Character: Girlfriend (uncredited)

Vianca Johnson

Character: Field Worker (uncredited)

Andrew Kaempfer

Character: Chicago Cop (uncredited)

Tony Lawson

Character: Vendor (uncredited)

Rege Lewis

Character: Bystander (uncredited)

Malikha Mallette

Character: Little Walter's Girlfriend (uncredited)

Cerrone May

Character: Muddy's Band Member (uncredited)

Adaku Ononogbo

Character: Muddy Waters' Girlfriend (uncredited)

Catherine Pierce

Character: Shocked Bystander (uncredited)

Stephen Seidel

Character: Officer Brown (uncredited)

Derrick Simmons

Character: Dice Player (uncredited)