Matthew Perry

Character: Self (archive footage)

Morgan Fairchild

Character: Self

E. Martin Estrada

Character: Self - U.S. Attorney for the Central District of California

Katy Forrester

Character: Self - Journalist, The US Sun

Greg Kading

Character: Self - LAPD Detective, Ret.

Deborah Walker

Character: Self - Journalist, The Hollywood Reporter

David Feifel

Character: Self - Kadima Neuropsychiatry Institute

Anna David

Character: Self - Author, Party Girl

Hank Azaria

Character: Self - Actor & Matthew's Friend

Jennifer O'Neill

Character: Self - Former Celebrity Assistant

Jennifer Aniston

Character: Self - Actor & Co-Star (archive footage)

Mark Chavez

Character: Self - Physician (archive footage)

Courteney Cox

Character: Self - Actor & Co-Star (archive footage)

Savannah Guthrie

Character: Self - Co-Host, Today (archive footage)

Kenneth Iwamasa

Character: Self - Matthew's Personal Assistant (archive footage)

Marta Kauffman

Character: Self - Co-Creator, Friends (archive footage)

David Letterman

Character: Self - Host, Late Show with David Letterman (archive footage)

Cody McLaury

Character: Self - Ketamine Overdose Victim (archive footage)

Caitlin Morrison

Character: Self - Matthew's Sister (archive footage)

Keith Morrison

Character: Self - Matthew's Stepfather (archive footage)

John Bennett Perry

Character: Self - Matthew's Father (archive footage)

Salvador Plasencia

Character: Self - Physician (archive footage)

Jasveen Sangha

Character: Self - Ketamine Queen (archive footage)

Diane Sawyer

Character: Self - Journalist, ABC News (archive footage)

Lisa Kudrow

Character: Self (archive footage)

Matt LeBlanc

Character: Self (archive footage)

David Schwimmer

Character: Self (archive footage)

Julia Roberts

Character: Self (archive footage)

Erik Fleming

Character: Self - Director/Alleged 'Street Dealer' (archive footage)