Drew Barrymore

Character: Chloe (voice)

Piper Perabo

Character: Rachel Ashe Lynn

Andy Garcia

Character: Delgado (voice)

George López

Character: Papi (voice)

Paul Rodríguez

Character: Chico (voice)

Plácido Domingo

Character: Monte (voice)

Edward James Olmos

Character: Diablo (voice)

Loretta Devine

Character: Delta (voice)

Jamie Lee Curtis

Character: Aunt Viv

Luis Guzmán

Character: Chucho (voice)

Eddie 'Piolin' Sotelo

Character: Rafa (voice)

Carlos Juvera

Character: Tomás (voice)

Grey DeLisle

Character: Mother Dog (voice)

Manolo Cardona

Character: Sam Cortez

Leslie Mann

Character: Bimini (uncredited)

Cheech Marin

Character: Manuel (voice)

Michael Urie

Character: Sebastian (voice)

José María Yázpik

Character: Vasquez

Maury Sterling

Character: Rafferty

Jesús Ochoa

Character: Officer Ramirez

Eugenio Derbez

Character: Store Owner

Omar Leyva

Character: Ranger

Naomy Romo

Character: Ranger

Ali Hillis

Character: Angela

Marguerite Moreau

Character: Blair

Nick Zano

Character: Bryan

Gina Gallego

Character: Shelter Director

Alberto Reyes

Character: Bellman

Brandon Keener

Character: Waiter

Sal Lopez

Character: Ring Announcer

Giovanna Acha Aleman

Character: Museum Guide

Jack Plotnick

Character: Dog Nanny

Randall England

Character: Butler

James P. Bennett

Character: Bull Fighter (uncredited)

Mary Paz Mata

Character: Shaman Lady

Tomihuatzi Xelhuantzi

Character: Museum Security Guard

Mayra Sérbulo

Character: Poor Woman

Fernando Manzano

Character: Desk Sergeant