Whoopi Goldberg

Character: Ranger Margaret (voice)

David Spade

Character: Ranger Frank (voice)

E. G. Daily

Character: Tommy Pickles (voice)

Tara Strong

Character: Dilan "Dil" Pickles (voice)

Christine Cavanaugh

Character: Chuckie Finster (voice)

Kath Soucie

Character: Phil / Lil / Betty DeVille (voices)

Cheryl Chase

Character: Angelica Pickles (voice)

Tim Curry

Character: Rex Pester (voice)

Jack Riley

Character: Stuart 'Stu' Pickles (voice)

Busta Rhymes

Character: Reptar Wagon (voice)

Michael Bell

Character: Charles 'Chaz' Finster Sr. / Grandpa Boris Kropotkin / Drew Pickles (voice)

Joe Alaskey

Character: Grandpa Lou Pickles (voice)

Phil Proctor

Character: Howard DeVille / Igor (voice)

Cree Summer

Character: Susie Carmichael (voice)

Tress MacNeille

Character: Charlotte Pickles (voice)

Melanie Chartoff

Character: Didi Pickles / Minka Kropotkin (voice)

Hattie Winston

Character: Lucy Carmichael (voice)

Andrea Martin

Character: Aunt Miriam (voice)

Tony Jay

Character: Dr. Lipschitz (voice)

Abraham Benrubi

Character: Serge (voice)

Gregg Berger

Character: TV Announcer (voice)

Charlie Adler

Character: United Express Driver (voice)

Mary Gross

Character: Female Guest (voice)

Edie McClurg

Character: Nurse (voice)

Roger Clinton, Jr.

Character: Air Crewman (voice)

Margaret Cho

Character: Lt. Klavin (voice)

Iggy Pop

Character: Newborn Baby (singing voice)

Louis Fresse

Character: Newborn Baby (singing voice)

Lisa Loeb

Character: Newborn Baby (singing voice)

Lenny Kravitz

Character: Newborn Baby (singing voice)

Dawn Robinson

Character: Newborn Baby (singing voice)

Lou Rawls

Character: Newborn Baby (singing voice)

Kate Pierson

Character: Newborn Baby (singing voice)

Cindy Wilson

Character: Newborn Baby (singing voice)

Gordon Gano

Character: Newborn Baby (singing voice)

Laurie Anderson

Character: Newborn Baby (singing voice)

Malik Isaac Taylor

Character: Newborn Baby (singing voice)

Fred Schneider

Character: Newborn Baby (singing voice)

Jakob Dylan

Character: Newborn Baby (singing voice)

Patti Smith

Character: Newborn Baby (singing voice)

Beck

Character: Newborn Baby (singing voice)

Steve Zirnkilton

Character: Reporter (voice)

Frank Welker

Character: Spike / Monkeys / Scar Snout (voice) (uncredited)

Phife Dawg

Character: Newborn Baby (Singing Voice)