Gérard Depardieu

Character: Christopher Columbus

Armand Assante

Character: Sanchez

Sigourney Weaver

Character: Queen Isabella

Loren Dean

Character: Older Fernando

Ángela Molina

Character: Beatrix

Fernando Rey

Character: Marchena

Michael Wincott

Character: Adrian de Moxica

Kevin Dunn

Character: Captain Mendez

Tchéky Karyo

Character: Martín Alonso Pinzón

Frank Langella

Character: Santangel

Mark Margolis

Character: Bobadilla

Arnold Vosloo

Character: Guevara

Steven Waddington

Character: Bartolome

Fernando Guillén Cuervo

Character: Giacomo

Juan Diego Botto

Character: Diego

Fernando García Rimada

Character: King Ferdinand

Albert Vidal

Character: Hernando de Talavera

José Luis Ferrer

Character: Alonso de Bolaños

Jack Taylor

Character: Vicuna

Billy L. Sullivan

Character: Ten-Year-Old Fernando

John Heffernan

Character: Brother Buyl