Andree Maranda

Character: Sara

Mitch Cohen

Character: The Toxic Avenger

Jennifer Prichard

Character: Wanda

Cindy Manion

Character: Julie

Robert Prichard

Character: Slug

Gary Schneider

Character: Bozo

Pat Ryan

Character: Mayor Belgoody

Mark Torgl

Character: Melvin

Dick Martinsen

Character: Officer O'Clancy

Chris Liano

Character: Walter Harris

David Weiss

Character: Chief of Police

Dan Snow

Character: Cigar Face

Doug Isbecque

Character: Knuckles

Charles Lee Jr.

Character: Nipples

Patrick Kilpatrick

Character: Leroy

Larry Sulton

Character: Frank

Michael Russo

Character: Rico

Norma Pratt

Character: Mrs. Haskell

Andrew Craig

Character: Fred

Ryan Sexton

Character: Johnny

Sarabel Levinson

Character: Melvin's Mom

Al Pia

Character: Tom Wrightson

Reuben Guss

Character: Dr. Snodburger

Kenneth Kessler

Character: Toxic Avenger's Voice (voice)

Barbara Gurskey

Character: Barbie

Rick Collins

Character: Bully

Randy Schein

Character: Bozo's Friend

Richard Duggan

Character: Ice Cream Man

Donna Winter

Character: Mayor's Secretary

Marisa Tomei

Character: Health Club Girl (uncredited)