Sanaa Lathan

Character: Kenya McQueen

Simon Baker

Character: Brian Kelly

Blair Underwood

Character: Mark Harper

Wendy Raquel Robinson

Character: Cheryl

Taraji P. Henson

Character: Nedra

Golden Brooks

Character: Suzette

Mike Epps

Character: Walter

Donald Faison

Character: Nelson McQueen

Alfre Woodard

Character: Joyce McQueen

Earl Billings

Character: Edmund McQueen

Matt Malloy

Character: Edwin

Katharine Towne

Character: Leah Cahan

Stanley DeSantis

Character: Jack Pino

Marcus Brown

Character: Rashid Mohammed

Fuzzy Fantabulous

Character: DJ Fuzzy Fantabulous (voice)

Henry Simmons

Character: Kyle

Russell Hornsby

Character: Dr. Brockton

Tanisha Harper

Character: Stacy

Michelle Griffin

Character: Kiki

Kimberly Barnett

Character: Luna

Rose Rollins

Character: Lauren

K.C. Clyde

Character: Waiter

Lee Garlington

Character: Mrs. Cahan

Tonita Castro

Character: Maria

Gabriel Tigerman

Character: Darren

Rick Fitts

Character: Emcee

John Ratzenberger

Character: Brian's Father (uncredited)