Jake Gyllenhaal

Character: Donnie Darko

Jena Malone

Character: Gretchen Ross

James Duval

Character: Frank

Drew Barrymore

Character: Karen Pomeroy

Beth Grant

Character: Kitty Farmer

Maggie Gyllenhaal

Character: Elizabeth Darko

Mary McDonnell

Character: Rose Darko

Holmes Osborne

Character: Eddie Darko

Noah Wyle

Character: Prof. Kenneth Monnitoff

Katharine Ross

Character: Dr. Lilian Thurman

Patrick Swayze

Character: Jim Cunningham

Daveigh Chase

Character: Samantha Darko

Arthur Taxier

Character: Dr. Fisher

David St. James

Character: Bob Garland

Patience Cleveland

Character: Roberta Sparrow / Grandma Death

Jazzie Mahannah

Character: Joanie James

Jolene Purdy

Character: Cherita Chen

David Moreland

Character: Principal Cole

Kristina Malota

Character: Susie Bates

Marina Malota

Character: Emily Bates

Scotty Leavenworth

Character: David

Phyllis Lyons

Character: Anne Fisher

Gary Lundy

Character: Sean Smith

Alex Greenwald

Character: Seth Devlin

Stuart Stone

Character: Ronald Fisher

Joan Blair

Character: Mystery Woman

Seth Rogen

Character: Ricky Danforth

Mark Hoffman

Character: Police Officer

Jerry Trainor

Character: Lanky Kid

Tom Tangen

Character: Man in Red Jogging Suit

Carly Naples

Character: Suzy Bailey

Lisa K. Wyatt

Character: Linda Connie

Rachel Winfree

Character: Shanda Riesman

Ashley Tisdale

Character: Kim

Tiler Peck

Character: Beth Farmer

Fran Kranz

Character: Passenger

Sarah Hudson

Character: Friend

Alison Jones

Character: Dorky Half-Sister

Lee Weaver

Character: Leroy

Jack Salvatore, Jr.

Character: Larry Riesman