E. G. Daily

Character: Tommy Pickles (voice)

Christine Cavanaugh

Character: Chuckie Finster (voice)

Cheryl Chase

Character: Angelica Pickles (voice)

Susan Sarandon

Character: Coco LaBouche (voice)

John Lithgow

Character: Jean-Claude (voice)

Tara Strong

Character: Dil Pickles (voice)

Kath Soucie

Character: Lil Deville / Phil DeVille / Betty DeVille (voice)

Michael Bell

Character: Drew Pickles / Chaz Finster, Sr. (voice)

Cree Summer

Character: Susie Carmichael (voice)

Tress MacNeille

Character: Charlotte Pickles (voice)

Debbie Reynolds

Character: Lulu Pickles (voice)

Joe Alaskey

Character: Grandpa Lou Pickles (voice)

Mako

Character: Mr. Yamaguchi (voice)

Tim Curry

Character: Sumo Singer (voice)

Julia Kato

Character: Kira Watanabe-Finster (voice)

Billy West

Character: Sumo Singer (voice)

Dionne Quan

Character: Kimi Watanabe-Finster (voice)

Melanie Chartoff

Character: Didi Pickles (voice)

Casey Kasem

Character: Wedding DJ (voice)

Phil Proctor

Character: Howard DeVille (voice)

Lisa McClowry

Character: Princess (voice)

Dan Castellaneta

Character: Priest (voice)

Roger Rose

Character: Finster Wedding DJ (voice)

Kevin Michael Richardson

Character: Sumo Singer (voice)

Jack Riley

Character: Stu Pickles (voice)