Jeff Bridges

Character: Dr. Mark Powell

Kevin Spacey

Character: Prot

Mary McCormack

Character: Rachel Powell

Alfre Woodard

Character: Claudia Villars

David Patrick Kelly

Character: Howie

Saul Williams

Character: Ernie

Peter Gerety

Character: Sal

Celia Weston

Character: Mrs. Archer

Ajay Naidu

Character: Dr. Chakaraborty

Tracy Vilar

Character: Maria

Melanee Murray

Character: Bess

John Toles-Bey

Character: Russell

Kimberly Scott

Character: Joyce Trexler

Conchata Ferrell

Character: Betty McAllister

Vincent Laresca

Character: Navarro

Mark Christopher Lawrence

Character: Simms

Brian Howe

Character: Steve Becker

Mary Mara

Character: Abby

Tess McCarthy

Character: Natalie Powell - Age 6

Natasha Dorfhuber

Character: Gabby Powell - Age 9

Brandon de Paul

Character: Josh - Age 10

Aaron Paul

Character: Michael Powell - Age 21

William Lucking

Character: Sheriff

Kelly Connell

Character: Walter Fleen

Peter Maloney

Character: Duncan Flynn

Lance E. Nichols

Character: David Patel

Paul Linke

Character: Stuart Hessler

Christopher Jason Brown

Character: Danny Trexler

Greg Lewis

Character: Dominic McAllister

Clarke Peters

Character: Homeless Veteran

Olga Merediz

Character: Transit Officer

Joe Holt

Character: Transit Officer

Lola Pashalinski

Character: Russian Woman

Kateri Walker

Character: Sara Porter

Katya Abelski

Character: Rebecca Porter

Scott Lincoln

Character: Walker

Clebert Ford

Character: Homeless Man

Norman Alden

Character: Babbling Man

Rawle D. Lewis

Character: Security Guard

Erik LaRay Harvey

Character: Security Guard

Zofia Borucka

Character: Woman on Train

Tony Rhune

Character: Thug

Vince Cupone

Character: Thug

Anne Carroll

Character: Ward Patient

Lisa Cohen

Character: Ward Patient

Clete Francis

Character: Ward Patient

Valerie Giocondo

Character: Ward Patient

Pat Jankiewicz

Character: Ward Patient

Joseph Steven

Character: Ward Patient

Coco Leigh

Character: Ward Patient

Rafael Real

Character: Ward Patient

Julie Sands

Character: Ward Patient

Gene Smith

Character: Ward Patient

Curt Clendenin

Character: Hospital Patient (uncredited)

Frank Collison

Character: Screaming Man (uncredited)

Moet Meira

Character: Jennifer (uncredited)

Paulo Pascoal

Character: Thief (Uncredited)

Mark Alkofer

Character: Subway Commuter (uncredited)

Ted Hollis

Character: Ward Doctor (uncredited)

Randy Springer

Character: Lab Tech (uncredited)