Robert Downey Jr.

Character: Steve Lopez

Jamie Foxx

Character: Nathaniel Ayers

Catherine Keener

Character: Mary Weston

Tom Hollander

Character: Graham Claydon

Nelsan Ellis

Character: David Carter

Michael Bunin

Character: Adam Crane

LisaGay Hamilton

Character: Jennifer Ayers

Rachael Harris

Character: Leslie Bloom

Stephen Root

Character: Curt Reynolds

Lorraine Toussaint

Character: Flo Ayers

Jena Malone

Character: Cheery Lab Tech

Octavia Spencer

Character: Troubled Woman

Justin Martin

Character: Young Nathaniel

Kokayi Ampah

Character: Bernie Carpenter

Patrick Tatten

Character: Paul Jr.

Susane Lee

Character: Marisa

Marcos De Silvas

Character: Mayor Villaigosa

Ilia Volok

Character: Harry Barnoff

Mike Nowak

Character: Julliard Conductor

David Jean Thomas

Character: Angry Homeless Man

Lemon Andersen

Character: Uncle Tommy

Kevin Michael Key

Character: Homeless Transvestite

Moya Brady

Character: Barely Dressed Woman

Orlando Ashley

Character: LAMP Homeless Guy

Artel Great

Character: Leon

J.J. Boone

Character: Shouting Woman

Annie McKnight

Character: LAMP Advocate

Bernadette Speakes

Character: Homeless Lady

Anna Levin

Character: Leeann

Steve Foster

Character: Steve

Vivian George

Character: Teresa

Kevin Cohen

Character: KK

Courtney Andre

Character: Courtney

Teri Hughes

Character: Detroit

Linda Harris

Character: Linda

Albert Olson

Character: Bam Bam

Melissa Black

Character: Melissa

Valarie Hudspeth

Character: Mama Grouch

Darryl Black St.

Character: Darryl

Kiana Parker

Character: Kiana

Hazard Banner

Character: Hazard

Russell Brown

Character: Russell

Jacqueline Sue West

Character: Jackie

Joyre Manuel

Character: Ashley

Lorinda Hawkins

Character: Singing Woman

Annette Valley

Character: Annette

Patrick Kelly

Character: Patrick

Quiana Farrow

Character: Quiana

Tony Genaro

Character: Globe Lobby Guard

Charlie Weirauch

Character: Atheist

Wayne Lopez

Character: Cop with Tents

Joe Hernandez-Kolski

Character: EMT #1

Noel Gugliemi

Character: Winston Street Cop

Paul Cruz

Character: EMT #2

Wil Garret

Character: Homeless Man

Halbert Hernandez

Character: EMT #3

Alejandro Patiño

Character: Construction Worker

Karole Selmon

Character: Homeless Woman #1

Rob Nagle

Character: Neil

Patricia Place

Character: Cello Donor

Ralph Cole Jr.

Character: Enraged Homeless Man

Gladys Khan

Character: Reception Nurse

Palma Lawrence Reed

Character: ER Nurse

Isabel Hubmann

Character: Laid-off Employee

Bonita Jefferson

Character: Homeless Woman #2

Eshana O'Neal

Character: Winston Street Prostitute

Myia Hubbard

Character: Young Jennifer Ayers

Iyanna Newborn

Character: Miss Little John

Bronwyn Hardy

Character: Beauty Shop Girl

Troy Blendell

Character: News Editor

Nick Nervies

Character: Jennifer's Son

Paul Norwood

Character: Editor

Wally Lozano

Character: Sign Spinner (uncredited)

Siso Kamburov

Character: Disney Hall Patron (uncredited)