Babe Ruth

Character: Babe (as George Herman 'Babe' Ruth)

Ruth Taylor

Character: Mildred Tobin

William Sheer

Character: Harry Knight

Margaret Seddon

Character: Babe's Mother

Frances Victory

Character: Pigtails

James A. Marcus

Character: Simon Tobin

Ralf Harolde

Character: John Tobin (as Ralph Harolds)

Charles Byer

Character: David Talmadge (as Charles Burt)

George Halpin

Character: Doc Hedges / The Constable / Dog Catcher

William J. Gross

Character: Eliar Lott

Walter Lawrence

Character: Tony Marino

Ann Brody

Character: Mrs. Tony Marino (as Anne Brodie)

Ricca Allen

Character: Almira Worters

Sammy Blum

Character: Jimbo Jones (as Sam Blum)

Ethel Kerwin

Character: Kitty Wilson

Tom Cameron

Character: Deacon Flack (as Thomas Cameron)

Charles J. Hunt

Character: Reverend David Talmadge