Ben Stiller

Character: Larry Daley

Amy Adams

Character: Amelia Earhart

Owen Wilson

Character: Jedediah Smith

Hank Azaria

Character: Kahmunrah / The Thinker / Abe Lincoln

Robin Williams

Character: Theodore Roosevelt

Christopher Guest

Character: Ivan the Terrible

Alain Chabat

Character: Napoleon Bonaparte

Steve Coogan

Character: Octavius

Ricky Gervais

Character: Dr. McPhee

Bill Hader

Character: George Armstrong Custer

Jon Bernthal

Character: Al Capone

Patrick Gallagher

Character: Attila the Hun

Jake Cherry

Character: Nicky Daley

Rami Malek

Character: Ahkmenrah

Mizuo Peck

Character: Sacajawea

Kerry van der Griend

Character: Neanderthal #1

Matthew Harrison

Character: Neanderthal #2

Rick Dobran

Character: Neanderthal #3

Randy Lee

Character: Hun #1

Darryl Quon

Character: Hun #2

Gerald Wong

Character: Hun #3

Paul Cheng

Character: Hun #4

Jay Baruchel

Character: Sailor Joey Motorola

Mindy Kaling

Character: Docent

Keith Powell

Character: Tuskegee Airman #1

Craig Robinson

Character: Tuskegee Airman #2

Samuel Patrick Chu

Character: Teenage Boy #1

Augustus Oicle

Character: Teenage Boy #2

Kai James

Character: Teenage Boy #3

Clint Howard

Character: Air and Space Mission Control Tech #1

Matty Finochio

Character: Air and Space Mission Control Tech #2

George Foreman

Character: George Foreman

Josh Byer

Character: Capone Gangster #1

Sophie Levy

Character: Young Girl #1

Tess Levy

Character: Young Girl #2

Christina Schild

Character: 'American Gothic' Woman

Robert Thurston

Character: 'American Gothic' Farmer

Alberta Mayne

Character: Kissing Nurse

Clifton MaCabe Murray

Character: Kissing Sailor

Caroll Spinney

Character: Oscar the Grouch (voice)

Thomas Morley

Character: Darth Vader

Dan Joffre

Character: Town Car Driver

Dave Hospes

Character: Astronaut

Regina Taufen

Character: New York Reporter

Shawn Levy

Character: Infomercial Father

Joe Jonas

Character: Cherub #1 (voice)

Kevin Jonas

Character: Cherub #2 (voice)

Nick Jonas

Character: Cherub #3 (voice)

Eugene Levy

Character: Albert Einstein (voice)

Brad Garrett

Character: Easter Island Head (voice)

Ed Helms

Character: Larry Daley's Assistant (uncredited)

Jonah Hill

Character: Brundon the Security Guard (uncredited)

Thomas Lennon

Character: Wilbur Wright (uncredited)

Crystal the Monkey

Character: Dexter / Able (uncredited)