Sam Rockwell

Character: Darwin the Guinea Pig (voice)

Jon Favreau

Character: Hurley the Guinea Pig (voice)

Tracy Morgan

Character: Blaster the Guinea Pig (voice)

Penélope Cruz

Character: Juarez the Guinea Pig (voice)

Nicolas Cage

Character: Speckles the Mole (voice)

Dee Bradley Baker

Character: Mooch the Fly (voice)

Bill Nighy

Character: Leonard Saber

Will Arnett

Character: Kip Killian

Zach Galifianakis

Character: Ben

Kelli Garner

Character: Marcie

Steve Buscemi

Character: Bucky the Hamster (voice)

Jared Lavette

Character: Jared the Skunk (voice)

Micah Lavette

Character: Micah the Fox (voice)

Niecy Nash-Betts

Character: Rosalita

Loudon Wainwright III

Character: Grandpa Goodman

Tyler Patrick Jones

Character: Connor

Piper Mackenzie Harris

Character: Penny

Chris Ellis

Character: NSA Director

Gabriel Casseus

Character: Carter

Justin Mentell

Character: Terrell

Troy Robinson

Character: Agent

Travis Davis

Character: Agent

Corey Michael Eubanks

Character: Agent

Mini Anden

Character: Saber's Assistant

Camaron Engels

Character: Skateboarder #1 (as Cameron Engels)

Steve Kelso

Character: Agent

Max Favreau

Character: Mice (voice)

James Huang

Character: Agent

Jack Conley

Character: Agent Trigstad