Ioan Gruffudd

Character: Reed Richards / Mr. Fantastic

Jessica Alba

Character: Sue Richards / Invisible Woman

Chris Evans

Character: Johnny Storm / Human Torch

Michael Chiklis

Character: Ben Grimm / The Thing

Julian McMahon

Character: Victor von Doom / Doctor Doom

Laurence Fishburne

Character: Norrin Radd / Silver Surfer (voice)

Doug Jones

Character: Norrin Radd / Silver Surfer

Kerry Washington

Character: Alicia Masters

Andre Braugher

Character: General Hager

Beau Garrett

Character: Frankie Raye

Brian Posehn

Character: Priest

Zach Grenier

Character: James Sherman / Rafke

Kenneth Welsh

Character: Dr. Jeff Wagner

Kevin McNulty

Character: Baxter Building Doorman

Andy Stahl

Character: Tailor

Debbie Timuss

Character: Hot Party Girl #1

Moneca Delain

Character: Hot Party Girl #2

Yan-Kay Crystal Lowe

Character: Hot Party Girl #3

Vanessa Lachey

Character: Johnny's Wedding Date

Stan Lee

Character: Stan Lee - Rejected Wedding Guest

Gonzalo Menendez

Character: Lieutenant

Giuliana Rancic

Character: Entertainment Reporter

Lauren Sánchez Bezos

Character: Fox News Reporter

Benjamin Ayres

Character: Guard #1

Patricia Harras

Character: Fan Four Receptionist

Fareed Abdelhak

Character: Egyptian Tour Guide

Dawn Chubai

Character: Anchorwoman

Alicia Thorgrimsson

Character: New York Pedestrian

Valerie Tian

Character: New York Teen Girl #1

Jeanna Haddow

Character: New York Teen Girl #2

Ali Costigan

Character: New York Teen Girl #3

Suzanne Ristic

Character: Airline Woman

Michasha Armstrong

Character: Wedding Security

Ulla Friis

Character: Danish News Anchor (uncredited)

Nimet Kanji

Character: Tourist in Egypt (uncredited)