Charlie Cox

Character: Tristan Thorn

Claire Danes

Character: Yvaine

Michelle Pfeiffer

Character: Lamia

Mark Strong

Character: Septimus

Jason Flemyng

Character: Primus

Robert De Niro

Character: Captain Shakespeare

Sienna Miller

Character: Victoria

Sarah Alexander

Character: Empusa

Joanna Scanlan

Character: Mormo

Melanie Hill

Character: Ditchwater Sal

Mark Heap

Character: Tertius

Rupert Everett

Character: Secundus

David Walliams

Character: Sextus

Adam Buxton

Character: Quintus

Julian Rhind-Tutt

Character: Quartus

Peter O'Toole

Character: King

Kate Magowan

Character: Una / Slave Girl

Jake Curran

Character: Bernard

David Kelly

Character: Guard

Nathaniel Parker

Character: Dunstan Thorn

Ricky Gervais

Character: Ferdy the Fence

Dexter Fletcher

Character: Skinny Pirate

Henry Cavill

Character: Humphrey

Mark Williams

Character: Billy

Olivia Grant

Character: Girl Bernard

Ian McKellen

Character: Narrator (voice)

Ben Barnes

Character: Young Dunstan Thorn

Bimbo Hart

Character: Young Scientist

Alastair MacIntosh

Character: Victorian Academic

Darby Hawker

Character: Grumpy Customer

Frank Ellis

Character: Mr. Monday

Struan Rodger

Character: Bishop

George Innes

Character: Soothsayer

Grant Burgin

Character: Lackey

Eliot Sumner

Character: Yvaine's Sister

Terry Murphy

Character: Old Pirate

Geoff Bell

Character: Receptionist

Mark Burns

Character: New Bishop

Rab Affleck

Character: Pirate

Carlos Besse Peres

Character: Pirate

Elwin 'Chopper' David

Character: Pirate

Adam Fogerty

Character: Pirate

Jordan Long

Character: Pirate

Spencer Wilding

Character: Pirate

Philip Harvey

Character: Bishop's Assistant