Diego Luna

Character: Manolo (voice)

Channing Tatum

Character: Joaquin (voice)

Zoe Saldaña

Character: Maria (voice)

Christina Applegate

Character: Mary Beth (voice)

Eugenio Derbez

Character: Chato (voice)

Cheech Marin

Character: Pancho Rodriguez (voice)

Gabriel Iglesias

Character: Pepe Rodriguez (voice)

Ron Perlman

Character: Xibalba (voice)

Kate del Castillo

Character: La Muerte (voice)

Ana de la Reguera

Character: Carmen Sánchez (voice)

Dan Navarro

Character: Chakal (voice)

Ice Cube

Character: Candle Maker (voice)

Héctor Elizondo

Character: Carlos Sanchez (voice)

Danny Trejo

Character: Skeleton Luis (voice)

Carlos Alazraqui

Character: General Posada / Dali / Chuy (voice)

Emil-Bastien Bouffard

Character: Young Manolo (voice)

Elijah Rodriguez

Character: Young Joaquin

Genesis Ochoa

Character: Young Maria (voice)

Plácido Domingo

Character: Skeleton Jorge (voice)

Grey DeLisle

Character: Grandmother (voice) (as Grey Griffin)

Trey Bumpass

Character: Goth Kid / Orphan

Miguel Sandoval

Character: Land of the Remembered Captain (voice)

Ben Gleib

Character: Goya / Dali (voice)

Ricardo El Mandril Sanchez

Character: Pablo Rodriguez (voice)

Ishan Sharma

Character: Sanjay

Jorge R. Gutierrez

Character: Skeleton Carmelo (voice)

Anjelah Johnson-Reyes

Character: Adelita / Nina (voice)

Kennedy Peil

Character: Sasha (voice)

Sandra Equihua

Character: Scardelita (voice)

Callahan Clark

Character: Jane (voice)

Gunnar Sizemore

Character: Ignacio (voice)

Angélica María

Character: Sister Ana (voice)

Eric Bauza

Character: Father Domingo / Cave Guardian (voice)

Aron Warner

Character: Thomas (voice)

Sandra Echeverría

Character: Claudia (voice)

Tonita Castro

Character: La Muerte as Old Woman (voice)

Troy Evans

Character: Old Man Hemingway (voice)

Guillermo del Toro

Character: Land of the Remembered Captain's Wife (voice)

Brad Booker

Character: Conductor (voice)

Rosemary Alexander

Character: Additional Voices (voice)

Steve Alterman

Character: Additional Voices (voice)

Eva Bella

Character: Additional Voices (voice)

Madison Carlon

Character: Additional Voices (voice)

Vicki Davis

Character: Additional Voices (voice)

Moosie Drier

Character: Additional Voices (voice)

Cullen McCarthy

Character: Additional Voices (voice)

David Michie

Character: Additional Voices (voice)

Michelle Moores

Character: Additional Voices (voice)

Jonathan Nichols-Navarro

Character: Additional Voices (voice)

Al Rodrigo

Character: Additional Voices (voice)

Marcelo Tubert

Character: Additional Voices (voice)

Lynnanne Zager

Character: Additional Voices (voice)

Ruth Zalduondo

Character: Additional Voices (voice)

Newell Alexander

Character: Additional Voices (voice)

David Cowgill

Character: Additional Voices (voice)

Elisa Gabrielli

Character: Additional Voices (voice)

Richard Miro

Character: Additional Voices (voice)

Arthur Ortiz

Character: Additional Voices (voice)

Nathaniel Semsen

Character: Additional Voices (voice)

Joe Matthews

Character: Young Manolo (singer)

Jose Alvarez

Character: Additional Voices (voice) (uncredited)