Tom Papa

Character: El Superbeasto (voice)

Joe Alaskey

Character: Erik the Newscaster (voice)

Ken Foree

Character: Luke St. Luke (voice)

April Winchell

Character: Dame Grace Appleton / Liza / Babs / Dolly / Joan / Gloria / Scripty / Helga Strudel (voice)

Dee Wallace

Character: Trixie (voice)

Laraine Newman

Character: Lefty / Kate / Courtney / Smelga Strudel / Betty Sue Lou (voice)

Cassandra Peterson

Character: Amber (voice)

Jess Harnell

Character: Uncle Carl (voice)

Harland Williams

Character: Gerard the Exterminator (voice)

Rob Paulsen

Character: Michael / Commercial Voice / Bobby Hyde / Commandant Hess / Assistant Cameraman / El Gato / Grossburger / Creature Preacher (voice)

Debra Wilson

Character: Cigarette Girl / Bride Fronkenstein / Female Patron / Stripper in Hall / Telephone Victim / Old Woman (voice)

Tom Klein

Character: Mr. Fly (voice)

Sheri Moon Zombie

Character: Suzi X (voice)

Brian Posehn

Character: Murray (voice)

Tom Kenny

Character: Rover / Otto / Old Man / Herbie (voice)

Dee Bradley Baker

Character: Nazi Zombie (voice)

Paul Giamatti

Character: Dr. Satan (voice)

Geoffrey Lewis

Character: Lenny (voice)

Rosario Dawson

Character: Velvet Von Black (voice)

John DiMaggio

Character: Burt the Spurt (voice)

Jeff Bennett

Character: Nerdy Patron (voice)

Danny Trejo

Character: Rico (voice)

Carlos Alazraqui

Character: Bennie Redriguez (voice)

Tura Satana

Character: Varla (voice)

Bill Moseley

Character: Otis Driftwood (voice)

Rodger Bumpass

Character: Screaming Patron (voice)

Sid Haig

Character: Captain Spaulding (voice)

Charlie Adler

Character: Krongarr / Mooney McMoon / Albino Singer (voice)

Kevin Michael Richardson

Character: Santa Baby (voice)

Daniel Roebuck

Character: Morris Green (voice)

Christopher Corey Smith

Character: Walla Voodoo (voice)

Zach Hanks

Character: Walla Voodoo (voice)

Ezra Weisz

Character: Walla Voodoo (voice)

Karen Strassman

Character: Walla Voodoo (voice)