Chris Massoglia

Character: Darren Shan

John C. Reilly

Character: Larten Crepsley

Josh Hutcherson

Character: Steve

Patrick Fugit

Character: Evra the Snake Boy

Salma Hayek Pinault

Character: Madame Truska

Jessica Carlson

Character: Rebecca

Michael Cerveris

Character: Mr. Tiny

Ray Stevenson

Character: Murlaugh

Morgan Saylor

Character: Annie

Don McManus

Character: Mr. Shan

Ken Watanabe

Character: Mr. Tall

Orlando Jones

Character: Alexander Ribs

Frankie Faison

Character: Rhamus Twobellies

Willem Dafoe

Character: Gavner Purl

Kristen Schaal

Character: Gertha Teeth

Patrick Breen

Character: Mr. Kersey

Tom Woodruff Jr.

Character: Wolfman

Jane Krakowski

Character: Corma Limbs

Drew Rin Varick

Character: Loaf Head

Colleen Camp

Character: Mrs. Shan

Lo Graham

Character: Student in Hallway and Classroom

Beau Holden

Character: Trucker

Trey Burvant

Character: Singing Dad

Daniel Newman

Character: Pete

Brandon Molale

Character: Vampaneze (uncredited)

Gino Galento

Character: Madame Truska's Man (uncredited)

Sam Medina

Character: Madame Truska's Man (uncredited)

Cody Klop

Character: Voice