Steve Martin

Character: Neal Page

John Candy

Character: Del Griffith

Laila Robins

Character: Susan Page

Michael McKean

Character: State Trooper

Dylan Baker

Character: Owen

Kevin Bacon

Character: Taxi Racer

Olivia Burnette

Character: Marti Page

Carol Bruce

Character: Joy Page

Diana Douglas

Character: Peg

Martin Ferrero

Character: Motel Clerk

Larry Hankin

Character: Doobie

Richard Herd

Character: Walt

Susan Kellermann

Character: Waitress

Matthew Lawrence

Character: Little Neal

Edie McClurg

Character: Car Rental Agent

Susan Isaacs

Character: Marie

John Randolph Jones

Character: Cab Dispatcher

Ben Stein

Character: Wichita Airport Rep

Lyman Ward

Character: John

George Petrie

Character: Martin

Gary Riley

Character: Motel Thief

Charles Tyner

Character: Gus

Lulie Newcomb

Character: Owen's Wife

Nicholas Wyman

Character: New York Lawyer

Gaetano Lisi

Character: Cab Driver - New York

Diana Castle

Character: Stewardess #1

Julie H. Morgan

Character: Stewardess #2

Bill Erwin

Character: Man on Plane

Ruth de Sosa

Character: New York Ticket Agent

Kim Genelle

Character: Receptionist

Grant Forsberg

Character: Brand Manager

David Raiport

Character: Cafe Patron

Andrew J. Hentz

Character: Bus Lover

Karen Meisinger

Character: Bus Loverette

Gary Palmer

Character: Pilot

John Moio

Character: Screaming Driver

Victoria Vanderkloot

Character: Screaming Driver's Wife

William Windom

Character: Mr. Bryant

Troy Evans

Character: Antisocial Trucker

George Sasaki

Character: Plane Passenger (uncredited)