Sid Haig

Character: Captain Spaulding

Bill Moseley

Character: Otis B. Driftwood

Sheri Moon Zombie

Character: Baby Firefly

Karen Black

Character: Mother Firefly

Erin Daniels

Character: Denise Willis

Chris Hardwick

Character: Jerry Goldsmith

Rainn Wilson

Character: Bill Hudley

Jennifer Jostyn

Character: Mary Knowles

Tom Towles

Character: Lieutenant George Wydell

Walton Goggins

Character: Deputy Steve Naish

Matthew McGrory

Character: Tiny Firefly

Robert Allen Mukes

Character: Rufus 'RJ' Firefly Jr.

Dennis Fimple

Character: Grandpa Hugo Firefly

Jake McKinnon

Character: Rufus 'Earl' Firefly Sr.

Harrison Young

Character: Don Willis

Irwin Keyes

Character: Ravelli

Michael J. Pollard

Character: Stucky

Chad Bannon

Character: Killer Karl

William Bassett

Character: Sheriff Frank Huston

David Reynolds

Character: Richard 'Little Dick' Wick

Joe Dobbs III

Character: Gerry Ober

Judith Drake

Character: Skunk Ape Wife

Gregg Gibbs

Character: Dr. Wolfenstein

Ken Johnson

Character: Skunk Ape Husband

Irvin Mosley Jr.

Character: Lewis Dover

Tom Towles

Character: George Wydell

Walter Phelan

Character: Dr. Satan

Rob Zombie

Character: Dr. Wolfenstein's assistant (uncredited)