John Goodman

Character: The Dean (segment "Happy Birthday")

Sydney Tamiia Poitier

Character: Hannah (segment "Happy Birthday")

Beverly D'Angelo

Character: Bag Lady (segment "Happy Birthday")

Christopher Lloyd

Character: Attorney Bum (segment "Happy Birthday")

David Hyde Pierce

Character: Barney (segment "Happy Birthday")

Caroline Rhea

Character: Monica (segment "Happy Birthday")

Jenica Bergere

Character: Sally (segment "Happy Birthday")

Ken Hudson Campbell

Character: Security Guard (segment "Happy Birthday")

Roman Danylo

Character: Donald (segment "Happy Birthday")

Kimiko Gelman

Character: May Lee Ha (segment "Happy Birthday")

Jean Kasem

Character: Nurse (segment "Happy Birthday")

Taylor Negron

Character: Policeman (segment "Happy Birthday")

Travis Wester

Character: Chute Boy (segment "Happy Birthday")

Dondré Whitfield

Character: Man in Elevator (segment "Happy Birthday")

Marissa Jaret Winokur

Character: Dean's Secretary (segment "Happy Birthday")

Bruce Davison

Character: (segment "The Other Side")

Anthony LaPaglia

Character: Dr. Maas (segment "The Other Side")

Karen Sillas

Character: Anna (segment "The Other Side")

Andie MacDowell

Character: Lisa (segment "Reaching Normal")

Paul Rudd

Character: Kenneth (segment "Reaching Normal")

Joey Lauren Adams

Character: Sarah (segment "Reaching Normal")

Alan Rosenberg

Character: Frank (segment "Reaching Normal")

Joel Grey

Character: Dr. Mensley (segment "Reaching Normal")

Jolene Blalock

Character: Charlie's Wife (wraparound segments)

Scott Lowell

Character: Charlie (wraparound segments)

Stephen Tobolowsky

Character: Tom (wraparound segments)

Kathleen Wilhoite

Character: Lucy (wraparound segments)

Ellen DeGeneres

Character: Operator (segment "Reaching Normal") (uncredited)

Helen Mirren

Character: Distinguished Woman (segment "Happy Birthday") (uncredited)