Ed Helms

Character: Rusty Griswold

Christina Applegate

Character: Debbie Griswold

Skyler Gisondo

Character: James Griswold

Steele Stebbins

Character: Kevin Griswold

Chris Hemsworth

Character: Stone Crandall

Leslie Mann

Character: Audrey Griswold

Chevy Chase

Character: Clark Griswold

Beverly D'Angelo

Character: Ellen Griswold

Charlie Day

Character: Chad

Catherine Missal

Character: Adena

Ron Livingston

Character: Ethan

Norman Reedus

Character: Trucker

Keegan-Michael Key

Character: Jack Peterson

Regina Hall

Character: Nancy Peterson

Emyri Crutchfield

Character: Sheila Peterson

Alkoya Brunson

Character: Gary Peterson

Nick Kroll

Character: Colorado Cop

Tim Heidecker

Character: Utah Cop

Kaitlin Olson

Character: Arizona Cop

Michael Peña

Character: New Mexico Cop

Hannah Jeter

Character: Ferrari Girl

David Clennon

Character: Harry Co-Pilot

Colin Hanks

Character: Jake

Kirstin Ford

Character: Mom on Plane

Ethan Maher

Character: Boy on Plane

Elizabeth Gillies

Character: Heather

Cristina Squyres

Character: Brooke

Nadine Avola

Character: Chelsea

Ryan Cartwright

Character: Terry

Valerie Payton

Character: Shuttle Driver

O'Clair Alexander

Character: Husky Lady at Monument

Miles Doleac

Character: Man on the Monument

Holly Gardner

Character: Women at Monument

R.F. Daley

Character: Furious Husband

Elizabeth Fendrick

Character: Furious Wife

Michael H. Cole

Character: Male Guest

Brooke Jaye Taylor

Character: Female Guest

Matthew Cornwell

Character: Male Guest #2

Mitchell Warren

Character: Wally World Kid #2

John Francis Daley

Character: Ride Operator

Brandon Michael Hale

Character: Gas Station Clerk (uncredited)

Libby Blake

Character: Boobs (uncredited)

Rick Ericson

Character: Hawaiian (uncredited)

Omar Lagudali

Character: Reporter (uncredited)

Cameron McIntyre

Character: Young James (age 7 / 9) (uncredited)

Jonathan Goldstein

Character: Hot Tub Guy (uncredited)

John C. McGinley

Character: Motorbike Cop

Samm Levine

Character: Festival Dude Sam (uncredited)