Bill Murray

Character: Don Johnston

Sharon Stone

Character: Laura

Jessica Lange

Character: Carmen

Tilda Swinton

Character: Penny

Frances Conroy

Character: Dora

Alexis Dziena

Character: Lolita

Chloë Sevigny

Character: Carmen's Assistant

Christopher McDonald

Character: Ron

Julie Delpy

Character: Sherry

Jeffrey Wright

Character: Winston

Heather Simms

Character: Mona

Chris Bauer

Character: Dan

Larry Fessenden

Character: Will

Brea Frazier

Character: Rita

Jarry Fall

Character: Winston and Mona's Kid

Korka Fall

Character: Winston and Mona's Kid

Saul Holland

Character: Winston and Mona's Kid

Zakira Holland

Character: Winston and Mona's Kid

Niles Lee Wilson

Character: Winston and Mona's Kid

Meredith Patterson

Character: Flight Attendant

Jennifer Rapp

Character: Girl on Bus

Nicole Abisinio

Character: Girl on Bus

Ryan Donowho

Character: Young Man on Bus

Dared Wright

Character: Rabbit Owner

Suzanne Hevner

Character: Mrs. Dorston

Brain McPeck

Character: Guy in S.U.V.

Matthew McAuley

Character: Guy in S.U.V.

Pell James

Character: Sun Green

Mark Webber

Character: The Kid

Homer Murray

Character: Kid in Car

Rachel Puchkoff

Character: Girl in House (uncredited) (unconfirmed)