Harry Connick Jr.

Character: Dr. Dennis Slamon

Tammy Blanchard

Character: Nicole Wilson

Amanda Bynes

Character: Jamie McGrath

Jennifer Coolidge

Character: Tish

Angie Harmon

Character: Lilly Tartikoff

John Benjamin Hickey

Character: Blake Rogers

Regina King

Character: Ellie Jackson

Swoosie Kurtz

Character: Elizabeth

Paula Cale

Character: Donna Slamon (as Paula Cale Lisbe)

Amy Madigan

Character: Fran Visco

Bernadette Peters

Character: Barbara Bradfield

Trudie Styler

Character: Tina

Melissa McBride

Character: Sally

J. Patrick McNamara

Character: Dr. Rice

Jackson Hurst

Character: Josh

Brandon Smith

Character: Pharmacy Board Member

Bruce McKinnon

Character: Dean Bradfield

Tom Nowicki

Character: Carl Reinhardt

William Ragsdale

Character: Andy Marks

Naima Lett

Character: Nurse Carol (as Naima Imani Lett)

Griff Furst

Character: Charlie Wilson

Maria Howell

Character: Kate

Joe Nemmers

Character: Ron Perelman

Rhoda Griffis

Character: Bindy Blake

Lance E. Nichols

Character: Dr. Brown

Louis Herthum

Character: Dr. Banks

Kim Wall

Character: Marci

Connor Hill

Character: Sam Wilson Age 5

Tyler Case

Character: Sam Wilson Age 7 and 8

Cooper Cason

Character: Sam Wilson Age 14

Sophia Watson

Character: Joey Lyn Slamon Age 7

Abby Rao

Character: Joey Lyn Slamon Age 9

Sam Richardson

Character: Matt Slamon Age 3 - 5

Ben Lux

Character: Matt Slamon Age 7 (as Benjamin Lux)

Austin Lux

Character: Matt Slamon Age 9

Elliott Grey

Character: Board Member

Andrew Matthews

Character: Darrin Bradfield

Evan Gamble

Character: Peter Wilson

Shanna Forrestall

Character: Runner