Emily Blunt

Character: Zoe Huntington (voice)

John Krasinski

Character: Owen Huntington (voice)

Lydia Rose Taylor

Character: Mackenzie Huntington (voice)

Ian McKellen

Character: Horatio P. Huntington (voice)

Sylvester Stallone

Character: Bullet-Man (voice)

Danny DeVito

Character: Chesterfield (voice)

Patrick Warburton

Character: Brock (voice)

Wallace Shawn

Character: Mr. Woodley (voice)

Raven-Symoné

Character: Brinkley (voice)

Gilbert Gottfried

Character: Mario Zucchini (voice)

Tara Strong

Character: Talia (voice)

Kevin Grevioux

Character: Samson the Strongman (voice)

Anthony Sava

Character: El Diablo (voice)

Brendan Sava

Character: Young Owen (voice)

Alyssa Trama

Character: Gretchen the Bearded Lady (voice)

Debi Derryberry

Character: Additional Voices (voice)

Harvey Fierstein

Character: Esmerelda (voice)

Grant George

Character: Additional Voices (voice)