Will Smith

Character: Dr. Bennet Omalu

Alec Baldwin

Character: Dr. Julian Bailes

Albert Brooks

Character: Dr. Cyril Wecht

Gugu Mbatha-Raw

Character: Prema Mutiso

David Morse

Character: Mike Webster

Arliss Howard

Character: Dr. Joseph Maroon

Mike O'Malley

Character: Daniel Sullivan

Eddie Marsan

Character: Dr. Steven DeKosky

Hill Harper

Character: Christopher Jones

Adewale Akinnuoye-Agbaje

Character: Dave Duerson

Stephen Moyer

Character: Dr. Ron Hamilton

Richard T. Jones

Character: Andre Waters

Paul Reiser

Character: Dr. Elliot Pellman

Luke Wilson

Character: Roger Goodell

Matthew Willig

Character: Justin Strzelczyk

Elizabeth Tulloch

Character: Keana Strzelczyk

Jason Davis

Character: Defense Attorney

Sara Lindsey

Character: Gracie

Kevin Jiggetts

Character: FBI Agent

Gary Grubbs

Character: FBI Agent

L. Scott Caldwell

Character: Waters' Mother

Joni Bovill

Character: Mrs. Scott

Joshua Elijah Reese

Character: Graveyard Tech

Holt McCallany

Character: Angry Neurologist

David Flick

Character: Hospital Security Guard

Kelley Davis

Character: Assistant

Samara Lee

Character: Strzelczyk's Daughter

Nathan Hollabaugh

Character: Young Reporter

Britanni Johnson

Character: Rachel Green

Randy Kovitz

Character: Deputy Mayor

Dan Ziskie

Character: Paul Tagliabue

Larry John Meyers

Character: Father D'Amico

Dan Anders

Character: College Coach

Jeb Keller

Character: High School Coach

Jackie Schafer

Character: TV Reporter (Webster Site)

Mike Clark

Character: TV Reporter (Interview)

Jared Pfennigwerth

Character: Tech

Phillip Chorba

Character: Tech

Alison Moir

Character: Colleen Bailes

Dino Rende

Character: Strzelczyk's Son

Cindy Jackson

Character: Paramedic

Scott Miller

Character: Contractor

Michael Schaich

Character: Security Guard

Hennessey Joseph

Character: NFL Employee

Antonia Long

Character: Piano Player

Lisa Earley

Character: Lodi Morgue Tech

Ann B. Betters

Character: Cantor

Joe Fishel

Character: Louisville Head Football Coach

Dihlon McManne

Character: Reporter at Westin

Brittney Aleah

Character: Altar Server (uncredited)

Christopher Boyer

Character: Crockett (uncredited)

Deborah Charity

Character: Attorney (uncredited)

Amy Lyn Elliott

Character: Business Woman (uncredited)

Joe Gallipoli

Character: Doctor (uncredited)

Carmen Gangale

Character: Doctor (uncredited)

Trevor Lee Georgeson

Character: NFL Mourner (uncredited)

David Gragg

Character: Football Coach (uncredited)

Eme Ikwuakor

Character: Amobi Okoye (uncredited)

Dontez James

Character: Corpse (uncredited)

Wendell Kinney

Character: NFL Football Player (uncredited)

David Dale McCue

Character: Pittsburgh Police Officer (uncredited)

Ben McDonnell

Character: Young Webster (uncredited)

Robert G. McKay

Character: Mr. Scott (uncredited)

F. Robert McMurray

Character: NFL Lawyer (uncredited)

Kimberly Ryans

Character: Business Woman (uncredited)

P. Scott Conner

Character: ER Doctor

Jared Scott

Character: Justin Strelczyk (uncredited)

Jackson Nunn

Character: Church Member (uncredited)