Sophie Nélisse

Character: Gilly Hopkins

Kathy Bates

Character: Maime Trotter

Glenn Close

Character: Nonnie Hopkins

Bill Cobbs

Character: Mr Randolph

Octavia Spencer

Character: Miss Harris

Julia Stiles

Character: Courtney Rutherford Hopkins

Clare Foley

Character: Agnes

Billy Magnussen

Character: Ellis

Zachary Hernandez

Character: W.E.

Sammy Pignalosa

Character: Rajeem

Toby Turner

Character: Ticket Agent

Richard Topol

Character: Principal Evans

Salvatore Rossi

Character: Stevie

Cameron Clifford

Character: Ed

Julee Cerda

Character: Mrs. Hong

Johanna Day

Character: Principal Maynard

Katherine Paterson

Character: Clerk

Frank Oz

Character: Cookie Monster (voice)

Blanca Camacho

Character: Additional Voices (voice)

Gavin Westerlind

Character: Ramirez

Sienna Stuebe

Character: Neighbor

Athena Stuebe

Character: Neighbor and Student

Loyzo

Character: Neighbor

Liz Imperio

Character: Neighbor

Connor Keegan Dosch

Character: School student

Cynthia Basinet

Character: Attendee

Cara Cooper

Character: Woman with Book